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  • ^ Wood, Lisa; Martin, Karen; Christian, Hayley; Nathan, Andrea; Lauritsen, Claire; Houghton, Steve; Kawachi, Ichiro; McCune, Sandra (2015). "The Pet Factor – Companion Animals as a Conduit for Getting to Know People, Friendship Formation and Social Support". PLoS ONE. 10 (4): e0122085. Bibcode:2015PLoSO..1022085W. doi:10.1371/journal.pone.0122085. PMC 4414420. PMID 25924013.
    A common breeding practice for pet dogs is mating between close relatives (e.g. between half- and full siblings).[81] Inbreeding depression is considered to be due largely to the expression of homozygous deleterious recessive mutations.[82] Outcrossing between unrelated individuals, including dogs of different breeds, results in the beneficial masking of deleterious recessive mutations in progeny.[83]
    

    In a study of seven breeds of dogs (Bernese mountain dog, basset hound, Cairn terrier, Epagneul Breton, German Shepherd dog, Leonberger, and West Highland white terrier) it was found that inbreeding decreases litter size and survival.[84] Another analysis of data on 42,855 dachshund litters found that as the inbreeding coefficient increased, litter size decreased and the percentage of stillborn puppies increased, thus indicating inbreeding depression.[85] In a study of boxer litters, 22% of puppies died before reaching 7 weeks of age.[86] Stillbirth was the most frequent cause of death, followed by infection. Mortality due to infection increased significantly with increases in inbreeding.[86]
    In domestic dogs, sexual maturity happens around six to twelve months of age for both males and females,[17][68] although this can be delayed until up to two years old for some large breeds. This is the time at which female dogs will have their first estrous cycle. They will experience subsequent estrous cycles semiannually, during which the body prepares for pregnancy. At the peak of the cycle, females will come into estrus, being mentally and physically receptive to copulation.[17] Because the ova survive and are capable of being fertilized for a week after ovulation, it is possible for more than one male to sire the same litter.[17]
    Long fur on the paws acts as a trap for grass seeds, grit, or even ice, so regular trimming is advisable. Use a pair of curved scissors with rounded tips. Work on one toe at a time and twirl the fur growing between two toes between your finger and thumb, and then snip the hair off at the base. Be careful never to pull on the fur, which elevates the skin and makes cutting it more likely. If you cannot see where the skin ends and the fur starts, then slide a comb through the fur at skin level, and using the scissors cut on the safe side of the comb. Repeat for each toe on each paw.
    Avoid getting water in the ears and eyes. If water does somehow get in the ears, use a small cotton ball or cotton pad (not a Q-tip, as it could go too far in) and gently wipe pat the inside of your dog's ear. Your dog will likely shake his head to remove water as well (like after a swim). If your dog seems to be scratching his/her ear constantly after bathing, take them to a vet to address the problem.
    ^ Jump up to: a b Axelsson, E.; Ratnakumar, A.; Arendt, M.L.; Maqbool, K.; Webster, M.T.; Perloski, M.; Liberg, O.; Arnemo, J.M.; Hedhammar, Å.; Lindblad-Toh, K. (2013). "The genomic signature of dog domestication reveals adaptation to a starch-rich diet". Nature. 495 (7441): 360–364. Bibcode:2013Natur.495..360A. doi:10.1038/nature11837. PMID 23354050.

    Despite their close genetic relationship and the ability to inter-breed, there are a number of diagnostic features to distinguish the gray wolves from domestic dogs. Domesticated dogs are clearly distinguishable from wolves by starch gel electrophoresis of red blood cell acid phosphatase.[41] The tympanic bullae are large, convex and almost spherical in gray wolves, while the bullae of dogs are smaller, compressed and slightly crumpled.[42] Compared with equally sized wolves, dogs tend to have 20% smaller skulls and 30% smaller brains.[43]:35 The teeth of gray wolves are also proportionately larger than those of dogs.[44] Dogs have a more domed forehead and a distinctive "stop" between forehead and nose.[45] The temporalis muscle that closes the jaws is more robust in wolves.[5]:p158 Wolves do not have dewclaws on their back legs, unless there has been admixture with dogs that had them.[46] Most dogs lack a functioning pre-caudal gland and enter estrus twice yearly, unlike gray wolves which only do so once a year.[47] So-called primitive dogs such as dingoes and Basenjis retain the yearly estrus cycle.[48]
    - Exclusions: Select cat furniture; cat toys; ORIJEN, ACANA, Taste of the Wild, Hill's Pet Nutrition food and treats (Hill's Prescription Diet, Hill's Science Diet, Hill's Ideal Balance and Hill's Bioactive Recipe); select Purina brands (Pro Plan, Muse, Beyond and and Tidy Cats); Petsafe Brands (PetSafe, SportDOG, Frolicat, Drinkwell, Solvit', ScoopFree, Pet Loo, Gentle Leader, Mr. Herzher's and Piddle Place); Educator E-Collars; Playology; Dollar per Gallon tanks, 50% off or more tanks; select Precious Cat litter products; select Zilla Critter Cages; WholeHearted Memberships, Repeat Delivery orders and subscriptions; out-of-stock items, prior purchases, Donations, Petco Gift Cards and eGift Cards.
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