^ Bridgett M. von Holdt, Emily Shuldiner, Ilana Janowitz Koch, Rebecca Y. Kartzinel, Andrew Hogan, Lauren Brubaker, Shelby Wanser4, Daniel Stahler, Clive D.L. Wynne, Elaine A. Ostrander, Janet S. Sinsheimer and Monique A.R. Udell (19 July 2017). "Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs". Science Advances. 3 (7): e1700398. Bibcode:2017SciA....3E0398V. doi:10.1126/sciadv.1700398. PMC 5517105. PMID 28776031.
A common breeding practice for pet dogs is mating between close relatives (e.g. between half- and full siblings).[81] Inbreeding depression is considered to be due largely to the expression of homozygous deleterious recessive mutations.[82] Outcrossing between unrelated individuals, including dogs of different breeds, results in the beneficial masking of deleterious recessive mutations in progeny.[83]
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A number of common human foods and household ingestibles are toxic to dogs, including chocolate solids (theobromine poisoning), onion and garlic (thiosulphate, sulfoxide or disulfide poisoning),[54] grapes and raisins, macadamia nuts, xylitol,[55] as well as various plants and other potentially ingested materials.[56][57] The nicotine in tobacco can also be dangerous. Dogs can be exposed to the substance by scavenging through garbage bins or ashtrays and eating cigars and cigarettes. Signs can be vomiting of large amounts (e.g., from eating cigar butts) or diarrhea. Some other signs are abdominal pain, loss of coordination, collapse, or death.[58] Dogs are susceptible to theobromine poisoning, typically from ingestion of chocolate. Theobromine is toxic to dogs because, although the dog's metabolism is capable of breaking down the chemical, the process is so slow that for some dogs even small amounts of chocolate can be fatal, especially dark chocolate.
Certain Pacific islands whose maritime settlers did not bring dogs, or where dogs died out after original settlement, notably: the Mariana Islands,[123] Palau,[124] Marshall Islands,[125] Gilbert Islands,[125] New Caledonia,[126] Vanuatu,[126][127] Tonga,[127] Marquesas,[127] Mangaia in the Cook Islands, Rapa Iti in French Polynesia, Easter Island,[127] Chatham Islands,[128] and Pitcairn Island (settled by the Bounty mutineers, who killed off their dogs in order to escape discovery by passing ships[129]).
Whether you love to know your dog is clean or you’re gearing up for family photos with him or her, a dog grooming salon can take care of everything. From baths to brushing, to even painting your dog’s nails, you can expect to pay a starting price of about $40 for a full grooming service (for a small dog). Grooming salons will mostly offer a basic package deal which can include a bath, trimmed nails, and cleaned ears. Dog grooming salons give special care to elderly dogs who might need to take frequent potty breaks or rests between services.

^ vonHoldt, Bridgett M.; Shuldiner, Emily; Koch, Ilana Janowitz; Kartzinel, Rebecca Y.; Hogan, Andrew; Brubaker, Lauren; Wanser, Shelby; Stahler, Daniel; Wynne, Clive D.L.; Ostrander, Elaine A.; Sinsheimer, Janet S.; Udell, Monique A.R. (1 July 2017). "Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs". Science Advances. 3 (7): e1700398. Bibcode:2017SciA....3E0398V. doi:10.1126/sciadv.1700398. PMC 5517105. PMID 28776031.

Unlike other domestic species which were primarily selected for production-related traits, dogs were initially selected for their behaviors.[96][97] In 2016, a study found that there were only 11 fixed genes that showed variation between wolves and dogs. These gene variations were unlikely to have been the result of natural evolution, and indicate selection on both morphology and behavior during dog domestication. These genes have been shown to affect the catecholamine synthesis pathway, with the majority of the genes affecting the fight-or-flight response[97][98] (i.e. selection for tameness), and emotional processing.[97] Dogs generally show reduced fear and aggression compared with wolves.[97][99] Some of these genes have been associated with aggression in some dog breeds, indicating their importance in both the initial domestication and then later in breed formation.[97] Traits of high sociability and lack of fear in dogs may include genetic modifications related to Williams-Beuren syndrome in humans, which cause hypersociability at the expense of problem solving ability.[100][101][102]
We continually review and update our pet grooming policies, procedures and standards, under the supervision of our Director of Veterinary Medicine, with counsel from a number of independent experts in animal care, behavior and ethics. We continue to train our teams on and reinforce the critical importance of following those policies at all times. Since 2015, we've worked together with the Pet Industry Joint Advisory Council (PIJAC) and the Professional Pet Groomers & Stylists Alliance (PPGSA) to encourage and support national health and safety standards for the grooming industry. We believe these standards are critical to the wellbeing of pets everywhere, and we continue to work with other pet industry leaders to encourage industry-wide adoption and adherence to them.
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