^ Bridgett M. von Holdt, Emily Shuldiner, Ilana Janowitz Koch, Rebecca Y. Kartzinel, Andrew Hogan, Lauren Brubaker, Shelby Wanser4, Daniel Stahler, Clive D.L. Wynne, Elaine A. Ostrander, Janet S. Sinsheimer and Monique A.R. Udell (19 July 2017). "Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs". Science Advances. 3 (7): e1700398. Bibcode:2017SciA....3E0398V. doi:10.1126/sciadv.1700398. PMC 5517105. PMID 28776031.
The domestic dog is the first species, and the only large carnivore, known to have been domesticated. Especially over the past 200 years, dogs have undergone rapid phenotypic change and were formed into today's modern dog breeds due to artificial selection by humans. These breeds can vary in size and weight from a 0.46 kg (1.0 lb) teacup poodle to a 90 kg (200 lb) giant mastiff. Phenotypic variation can include height measured to the withers ranging from 15.2 centimetres (6.0 in) in the Chihuahua to 76 cm (30 in) in the Irish Wolfhound; color varies from white through grays (usually called "blue") to black, and browns from light (tan) to dark ("red" or "chocolate") in a wide variation of patterns; coats can be short or long, coarse-haired to wool-like, straight, curly, or smooth.[131] The skull, body, and limb proportions vary significantly between breeds, with dogs displaying more phenotypic diversity than can be found within the entire order of carnivores. Some breeds demonstrate outstanding skills in herding, retrieving, scent detection, and guarding, which demonstrates the functional and behavioral diversity of dogs. The first dogs were domesticated from shared ancestors of modern wolves, however the phenotypic changes that coincided with the dog–wolf genetic divergence are not known.[26]
Citing a 2008 study, the U.S. Center for Disease Control estimated in 2015 that 4.5 million people in the USA are bitten by dogs each year.[176] A 2015 study estimated that 1.8% of the U.S. population is bitten each year.[177] In the 1980s and 1990s the US averaged 17 fatalities per year, while since 2007 this has increased to an average of 31.[178] 77% of dog bites are from the pet of family or friends, and 50% of attacks occur on the property of the dog's legal owner.[178]
Soak your dog thoroughly. Make sure your dog's coat is completely wet before you start applying shampoo to it. If your dog isn't afraid, you can buy and use a hose and water pressurizer attachment for the faucet. This is especially helpful if you have a large dog or one with a double-coat. AVOID getting water in your dog's ears. Water in the ears can cause an infection. Please be sure to only spray water/rinse water up to the dog's neck. The head can be cleaned separately (see below for instructions).

Cut out mats that can't be brushed out. Severe matting can pull the skin every time the dog moves, making daily life painful for your pet. If you can't brush a mat out, you need to either cut or shave it off, depending on how close it is to the skin. Be extremely careful if you use scissors to avoid injuring yourself or your pet. Try to cut parallel to the growth of the hair to avoid a choppy look.
The role of the dog in Chinese mythology includes a position as one of the twelve animals which cyclically represent years (the zodiacal dog). Three of the 88 constellations in western astronomy also represent dogs: Canis Major (the Great Dog, whose brightest star, Sirius, is also called the Dog Star), Canis Minor (the Little Dog), and Canes Venatici (the Hunting Dogs).
Despite their close genetic relationship and the ability to inter-breed, there are a number of diagnostic features to distinguish the gray wolves from domestic dogs. Domesticated dogs are clearly distinguishable from wolves by starch gel electrophoresis of red blood cell acid phosphatase.[41] The tympanic bullae are large, convex and almost spherical in gray wolves, while the bullae of dogs are smaller, compressed and slightly crumpled.[42] Compared with equally sized wolves, dogs tend to have 20% smaller skulls and 30% smaller brains.[43]:35 The teeth of gray wolves are also proportionately larger than those of dogs.[44] Dogs have a more domed forehead and a distinctive "stop" between forehead and nose.[45] The temporalis muscle that closes the jaws is more robust in wolves.[5]:p158 Wolves do not have dewclaws on their back legs, unless there has been admixture with dogs that had them.[46] Most dogs lack a functioning pre-caudal gland and enter estrus twice yearly, unlike gray wolves which only do so once a year.[47] So-called primitive dogs such as dingoes and Basenjis retain the yearly estrus cycle.[48]
If you are shy about touching certain parts of your dog, get over it. If you are going to clean your dog, you must clean your dog's whole body. If there are any fleas or ticks on your dog, let them sit for ten minutes after working in the flea and tick treatment shampoo. When the bugs are dead, make sure to fully wash all of them off. If they are left on, these could give your dog a disease. To get the ticks off, get your hemostats latched on the ticks head and pull outward so the head doesn't break off and stay in the body. This would include scrubbing all over your dog's body, even areas you are not comfortable with. Never use hot water, and be especially careful to avoid warm water or medicated shampoos on the genital area. This area is sensitive.
Whether you love to know your dog is clean or you’re gearing up for family photos with him or her, a dog grooming salon can take care of everything. From baths to brushing, to even painting your dog’s nails, you can expect to pay a starting price of about $40 for a full grooming service (for a small dog). Grooming salons will mostly offer a basic package deal which can include a bath, trimmed nails, and cleaned ears. Dog grooming salons give special care to elderly dogs who might need to take frequent potty breaks or rests between services.
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