^ Bridgett M. von Holdt, Emily Shuldiner, Ilana Janowitz Koch, Rebecca Y. Kartzinel, Andrew Hogan, Lauren Brubaker, Shelby Wanser4, Daniel Stahler, Clive D.L. Wynne, Elaine A. Ostrander, Janet S. Sinsheimer and Monique A.R. Udell (19 July 2017). "Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs". Science Advances. 3 (7): e1700398. Bibcode:2017SciA....3E0398V. doi:10.1126/sciadv.1700398. PMC 5517105. PMID 28776031.
^ Jump up to: a b Freedman, Adam H.; Gronau, Ilan; Schweizer, Rena M.; Ortega-Del Vecchyo, Diego; Han, Eunjung; Silva, Pedro M.; Galaverni, Marco; Fan, Zhenxin; Marx, Peter; Lorente-Galdos, Belen; Beale, Holly; Ramirez, Oscar; Hormozdiari, Farhad; Alkan, Can; Vilà, Carles; Squire, Kevin; Geffen, Eli; Kusak, Josip; Boyko, Adam R.; Parker, Heidi G.; Lee, Clarence; Tadigotla, Vasisht; Siepel, Adam; Bustamante, Carlos D.; Harkins, Timothy T.; Nelson, Stanley F.; Ostrander, Elaine A.; Marques-Bonet, Tomas; Wayne, Robert K.; Novembre, John (16 January 2014). "Genome Sequencing Highlights Genes Under Selection and the Dynamic Early History of Dogs". PLOS Genetics. 10 (1): e1004016. doi:10.1371/journal.pgen.1004016. PMC 3894170. PMID 24453982.
- Exclusions: Select cat furniture; cat toys; ORIJEN, ACANA, Taste of the Wild, Hill's Pet Nutrition food and treats (Hill's Prescription Diet, Hill's Science Diet, Hill's Ideal Balance and Hill's Bioactive Recipe); select Purina brands (Pro Plan, Muse, Beyond and and Tidy Cats); Petsafe Brands (PetSafe, SportDOG, Frolicat, Drinkwell, Solvit', ScoopFree, Pet Loo, Gentle Leader, Mr. Herzher's and Piddle Place); Educator E-Collars; Playology; Dollar per Gallon tanks, 50% off or more tanks; select Precious Cat litter products; select Zilla Critter Cages; WholeHearted Memberships, Repeat Delivery orders and subscriptions; out-of-stock items, prior purchases, Donations, Petco Gift Cards and eGift Cards.
Free Shipping Exclusions: JustFoodForDogs products; Cat litter, dog litter, ice melter, wild bird food, live fish & rock, aquatic gravel and accents; crickets, live food and frozen food; out-of-stock items, Donations, Petco or Unleashed by Petco Gift Cards and eGift Cards; items shipped through white glove delivery or LTL delivery; orders exceeding the maximum weight limit of 300 lbs.; and applicable taxes. Additional exclusions may apply and will be noted on the Product Detail page and/or Shopping Cart.
In mythology, dogs often serve as pets or as watchdogs.[208] Stories of dogs guarding the gates of the underworld recur throughout Indo-European mythologies[210][211] and may originate from Proto-Indo-European religion.[210][211] In Greek mythology, Cerberus is a three-headed watchdog who guards the gates of Hades.[208] In Norse mythology, a bloody, four-eyed dog called Garmr guards Helheim.[208] In Persian mythology, two four-eyed dogs guard the Chinvat Bridge.[208] In Welsh mythology, Annwn is guarded by Cŵn Annwn.[208] In Hindu mythology, Yama, the god of death, owns two watch dogs who have four eyes. They are said to watch over the gates of Naraka.[212]
In a study of seven breeds of dogs (Bernese mountain dog, basset hound, Cairn terrier, Epagneul Breton, German Shepherd dog, Leonberger, and West Highland white terrier) it was found that inbreeding decreases litter size and survival.[84] Another analysis of data on 42,855 dachshund litters found that as the inbreeding coefficient increased, litter size decreased and the percentage of stillborn puppies increased, thus indicating inbreeding depression.[85] In a study of boxer litters, 22% of puppies died before reaching 7 weeks of age.[86] Stillbirth was the most frequent cause of death, followed by infection. Mortality due to infection increased significantly with increases in inbreeding.[86]
^ Jump up to: a b Axelsson, E.; Ratnakumar, A.; Arendt, M.L.; Maqbool, K.; Webster, M.T.; Perloski, M.; Liberg, O.; Arnemo, J.M.; Hedhammar, Å.; Lindblad-Toh, K. (2013). "The genomic signature of dog domestication reveals adaptation to a starch-rich diet". Nature. 495 (7441): 360–364. Bibcode:2013Natur.495..360A. doi:10.1038/nature11837. PMID 23354050.

The genetic divergence between dogs and wolves occurred between 40,000–20,000 years ago, just before or during the Last Glacial Maximum.[27][2] This timespan represents the upper time-limit for the commencement of domestication because it is the time of divergence and not the time of domestication, which occurred later.[27][28] The domestication of animals commenced over 15,000 years ago, beginning with the grey wolf (Canis lupus) by nomadic hunter-gatherers.[27] The archaeological record and genetic analysis show the remains of the Bonn–Oberkassel dog buried beside humans 14,200 years ago to be the first undisputed dog, with disputed remains occurring 36,000 years ago.[2] It was not until 11,000 years ago that people living in the Near East entered into relationships with wild populations of aurochs, boar, sheep, and goats.[27]
The price of dog grooming starts around $40 for a full grooming service for a small dog, and around $75 for a large dog. If you have more than one, prices can be significantly lower for the second and third dog. For mobile grooming, where groomers come to you, a full service of ears, nails, anal glands, bath, blow dry, and scissor finish is about $75 for average size dogs.
In 2013, an estimate of the global dog population was 987 million.[104] Although it is said that the "dog is man's best friend",[105] this refers largely to the ~20% of dogs that live in developed countries. In the developing world, dogs are more commonly feral or communally owned, with pet dogs uncommon.[50] Most of these dogs live their lives as scavengers and have never been owned by humans, with one study showing their most common response when approached by strangers is to run away (52%) or respond aggressively (11%).[106] Little is known about these dogs, or the dogs in developed countries that are feral, stray or are in shelters, because the great majority of modern research on dog cognition has focused on pet dogs living in human homes.[107]
You may need to pluck ear hairs from time to time. Ask a veterinarian or professional groomer to show you how to pluck the hairs from your dog's ear safely and correctly. Ear powder makes the process easier and quicker by giving added gripping power to the slippery ear hairs. Be very careful when using hemostats as they may poke inside their ear if used incorrectly or when the dog jerks their head.

^ Bridgett M. von Holdt, Emily Shuldiner, Ilana Janowitz Koch, Rebecca Y. Kartzinel, Andrew Hogan, Lauren Brubaker, Shelby Wanser4, Daniel Stahler, Clive D.L. Wynne, Elaine A. Ostrander, Janet S. Sinsheimer and Monique A.R. Udell (19 July 2017). "Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs". Science Advances. 3 (7): e1700398. Bibcode:2017SciA....3E0398V. doi:10.1126/sciadv.1700398. PMC 5517105. PMID 28776031.


Clip the dog's hair methodically.[9] You can place the blade against the body safely, so long as you don't press the blade strongly into the skin. Brush against the direction of hair growth(back-brush) before running the clippers the other direction; with the direction of hair growth. Using the clippers against the growth of hair will have the same effect as back-brushing, but will leave a shorter length than the clipper blade that you are using. If you want to shave against the growth of hair, a blade size gets two blade sizes smaller when cutting against the grain. For example, when cutting with 4# against the grain check how long a 7# leaves behind when cutting with the grain. Move the clippers surely, but slowly across the dog's body to remove the hair — moving too fast might leave uneven lines. Always move the blade with the direction of the hairs' growth unless you want a shorter length than your blade claims to leave. Begin at the neck, then move down to the shoulders, under the ears, and toward the chin, throat, and chest areas. DO NOT use a size seven or any skip blades around the throat area or any flaps on the body that can fit between the teeth, such as the Achilles' tendons, arm pits, genital area, tip of tail, or anus. Then, clip the dog's back and sides. Finally, clip the hair on the dog's legs. Be careful when cutting the neck with any blade as it's the most dangerous to cut. Never cut straight down, do so at angles to avoid flaps you can't see in the neck getting cut.
As humans became more sophisticated, so did their dogs. Eventually, there emerged specific breeds of dogs, custom-bred to suit the breeders’ local needs and circumstances. The Greyhound, for instance, was the foundation type for the immense Irish Wolfhound and the dainty Italian Greyhound. All three have a distinct family resemblance, but you’d never mistake one for another.
Clear the dog's eyes. White-haired breeds or those with large eyes that water a lot (Pekingese, Pugs, Pomeranians, etc.) may need more maintenance in this area than others. Depending on your particular dog, this step may be a simple matter of wiping or pulling eye debris away from the corners of the eyes. Long-haired or white-haired dogs may need special attention to make sure that all gunk is out of the coat, as they may get tear stains. You can buy products made for removing "tear stains" from a white coat at a pet supply store.
×